徐德祥


1.简介

  医学博士、二级教授、博士生导师、省级教学名师、校学术委员会委员、国务院政府特殊津贴获得者、安徽省跨世纪学术技术带头人首批人选、安徽省高校拔尖人才、安徽省创新争先奖获得者、国家自然科学基金函审专家,国家自然科学基金重点项目和面上项目会审专家。研究方向:生殖发育毒理学和肝脏毒理学。行政兼职:安徽医科大学公共卫生学院副院长、环境毒理学安徽普通高校重点实验室主任和出生人口健康教育部重点实验室副主任。学术兼职:中国毒理学会毒理学教育专委会副主委、中华预防医学学会自由基医学分会副主委、中华预防医学学会卫生毒理学分会常委、中国妇幼健康促进会母胎医学专委会常委、中国毒理学会免疫毒理学分会常委、中国毒理学会生殖毒理学专委会委员、中国环境诱变剂学会理事、中国环境诱变剂学会生物标志物专委会常委、中国环境诱变剂学会暴露组学与暴露科学专委会常委、安徽省环境诱变剂学会理事长。科学研究:主持国家自然基金重点项目2项、重大研究计划培育项目1项、面上项目6项;以通讯作者发表SCI论文130篇;2014~2018连续5年入选药理学与毒理学”ELSEVIER中国高被引学者榜;以第一完成人获安徽省科学技术(自然科学)一等奖1项、二等奖2项、三等奖1项,中华医学科技奖2项、中华预防医学科技奖1项。专业与教材建设:省级示范专业——卫生检验与检疫学专业带头人,省级精品开放课程《毒理学基础》课程负责人,校级研究生精品课程《分子医学实验技术与方法》课程负责人,国家规划教材《毒理学基础》(人卫版)编委;《毒理学实验方法与技术》(人卫版)编委;《毒理学基础双语教材》(人卫版)编委;案例版教材《毒理学基础》(科技版)副主编;《毒理学实验方法与技术》(科技版)副主编

2.教育经历

2001/07-2004/06,安徽医科大学,药理学专业,博士研究生

1986/09-1989/07,复旦大学医学院,劳动卫生与职业病专业,硕士研究生

1979/09-1984/07,复旦大学医学院,预防医学专业,本科生

3.工作经历

2001/07-----至今,安徽医科大学,公共卫生学院,教授,博士生导师

1998/02-1999/02,新加坡国立大学医学院,高级访问学者

1996/07-2001/07,安徽医科大学,公共卫生学院,副教授

1991/07-1996/07,安徽医科大学,卫生系,讲师

4.主持科研项目

[1]国家自然科学基金重点项目,81930093,父代生殖细胞重编程关键期砷暴露跨代影响子代发育的表观遗传机制,297 万元,在研,主持人。

[2]国家自然科学基金重大研究计划培育项目,91743105,孕期1-硝基芘暴露与胎儿宫内生长受限的关联及其毒理学机制,80万元,在研,主持人。

[3]国家自然科学基金重点项目,81630084,孕期维生素D缺乏与胎儿生长受限的关联及其机制研究,275万元,在研,主持人。

[4]国家自然科学基金面上项目,81373495Toll样受体4在对乙酰氨基酚肝损伤不同阶段肝细胞程序性坏死和再生中的作用,2014/01-2017/1275万元,在研,主持人。

[5]国家自然科学基金面上项目,81172711,活性氧和一氧化氮介导的胎盘内质网应激在LPS致畸中的作用,2012/01-2015/1255万元,已结题,主持人。

[6]国家自然科学基金面上项目,ROSPGsNOTNF-αLPS调控肝细胞LXR-α及其靶基因中的作用,2010/01-2012/1235万元,已结题,主持人。

[7]国家自然科学基金面上项目,30671786Toll样受体信号通路下游分子ROSPGsNOTNF-αLPS致畸中的作用,2007/01-2009/1230万元,已结题,主持人。

[8]国家自然科学基金面上项目,细菌脂多糖对肝细胞孕烷X受体及其靶基因CYP3A的下调作用及其机理,2006/01-2008/1228万元,已结题,主持人。

[9]国家自然科学基金小额项目,ROSPGsTLR-4LPS下调肝细胞CYP3A基因表达中的作用,2004/01-2004/127万元,已结题,主持人。

5.代表性SCI论文(*通讯作者)

[1]Lu JW, Wang H, Ji YL, Zhang C, Ning H, Li XY, Zhang H, Duan ZH, Zhao L, Wei W, Xu DX*. Differential effects of pyrrolidine dithiocarbamate on TNF-α-mediated liver injury in two different models of fulminant hepatitis. J Hepatol 2008; 48: 442-452. (IF: 18.946)

[2]Xu DX*, Wang H, Ning H, Zhao L, Chen YH. Maternally administered melatonin differentially regulates lipopolysaccharide (LPS)-induced proinflammatory and antiinflammatory cytokines in maternal serum, amniotic fluid, fetal liver and fetal brain. J Pineal Res 2007; 43: 74-79. (IF: 15.211)

[3]Wang H, Li L, Zhao M, Chen YH, Zhang ZH, Zhang C, Ji YL, Meng XH, Xu DX*. Melatonin alleviates lipopolysaccharide-induced placental cellular stress response in mice. J Pineal Res 2011; 50: 418-426. (IF: 15.211)

[4]Ji YL, Wang H, Meng C, Zhao XF, Zhang C, Zhang Y, Zhao M, Chen YH, Meng XH, Xu DX*. Melatonin alleviates cadmium-induced cellular stress and germ cell apoptosis in testes. J Pineal Res 2012; 5: 71-79. (IF: 15.211)

[5]Chen YH, Xu DX*, Wang JP, Wang H, Wei LZ, Sun MF, Wei W. Melatonin protects against lipopolysaccharide-induced intra-uterine fetal death and growth retardation in mice. J Pineal Res 2006; 40: 40-47. (IF: 15.211)

[6]Xia MZ, Liang YL, Wang H, Chen X, Huang YY, Zhang ZH, Chen YH, Zhang C, Zhao M, Xu DX*, Song LH*. Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells. J Pineal Res 2012; 53: 325-334.(IF:15.211)

[7]Chen X, Zhang C, Zhao M, Shi CE, Zhu RM, Wang H, Zhao H, Wei W, Li JB, Xu DX*. Melatonin alleviates lipopolysaccharide-induced hepatic SREBP-1c activation and lipid accumulation in mice. J Pineal Res 2011; 51: 416-425. (IF: 15.211)

[8]Xu DX*, Wei W*, Sun MF, Wei LZ, Wang JP. Melatonin counteracts against LPS-induced oxidative stress and attenuates LPS-induced down-regulation of nuclear receptor pregnane X receptor and its target gene CYP3A in mouse liver. J Pineal Res 2005; 38: 27-34. (IF: 15.211)

[9]Xu DX*, Wei W*, Sun MF, Wu CY, Wang JP, Wei LZ, Zhou CF. Kupffer cells and ROS partially mediate LPS-induced down-regulation of nuclear receptor pregnane X receptor and its target gene CYP3A in mouse liver. Free Radic Biol Med 2004; 37: 10-22. (IF: 5.657)

[10]Zhao XF, Wang Q, Ji YL, Wang H, Liu P, Zhang C, Zhang Y, Xu DX*. Fenvalerate induces germ cell apoptosis in mouse testes through the Fas/FasL signaling pathway. Arch Toxicol 2011; 85: 1101-1108. (IF: 5.741)

[11]Wang H, Wang Q, Zhao XF, Liu P, Meng XH, Yu T, Ji YL, Zhang H, Zhang C, Zhang Y, Xu DX*. Cypermethrin Exposure during Puberty Disrupts Testosterone Synthesis via Downregulating StAR in Mouse Testes. Arch Toxicol 2010; 84: 53-61. (IF: 5.741)

[12]Li J, Wang H, Hao JH, Chen YH, Liu L, Yu Z, Fu L, Tao FB*, Xu DX*. Maternal serum lead level during pregnancy is positively correlated with risk of preterm birth in a Chinese population. Environ Pollut 2017; 227: 484-489.(IF: 5.714)

[13]Wang H, Liu L, Hu YF, Hao JH, Chen YH, Su PY, Yu Z, Fu L, Tao FB*, Xu DX*. Association of maternal serum cadmium level during pregnancy with risk of preterm birth in a Chinese population. Environ Pollut 2016; 216: 851-857.(IF: 5.714)

[14]Xu DX*, Chen YH, Zhao L, Wang H, Wei W. Reactive oxygen species are involved in lipopolysaccharide-induced intra-uterine growth restriction and skeletal development retardation in mice. Am J ObstetGynecol 2016; 195: 1707-1714. (IF: 6.120)

[15]Li J, Wang H, Hao JH, Chen YH, Liu L, Yu Z, Fu L, Tao FB, Xu DX*. Maternal serum lead level during pregnancy is positively correlated with risk of preterm birth in a Chinese population. Environ Pollut 2017; 227: 484-489. (IF: 5.714)

[16]Wang H, Liu L, Hu YF, Hao JH, Chen YH, Su PY, Yu Z, Fu L, Tao FB, Xu DX*. Association of maternal serum cadmium level during pregnancy with risk of preterm birth in a Chinese population. Environ Pollut 2016; 216: 851-857. (IF: 5.714)

[17]Chen YH, Fu L, Hao JH, Yu Z, Zhu P, Wang H, Xu YY, Zhang C, Tao FB*, Xu DX*. Maternal vitamin D deficiency during pregnancy elevates the risks of small for gestational age and low birth weight infants in Chinese population. J Clin Endocrinol Metab 2015; 100: 1912-1919. (IF: 5.605)

[18]Li R, Wang X, Wang B, Li J, Song Y, Luo B, Chen Y, Zhang C, Wang H, Xu D*. Gestational 1-nitropyrene exposure causes fetal growth restriction through disturbing placental vascularity and proliferation. Chemosphere 2018;213: 252-258.(IF: 5.108)

[19]Zhao S, Liu Y, Wang F, Xu DX*, Xie P. N-acetylcysteine protects against microcystin-LR-induced endoplasmic reticulum stress and germ cell apoptosis in zebrafish testes. Chemosphere 2018; 204:463-473.(IF: 5.108)

[20]Fu L, Chen YH, Bo QL, Song YP, Ma L, Wang B, Xu S, Zhang C, Wang H, Xu DX*. Lipopolysaccharide Downregulates 11β-Hydroxysteroid Dehydrogenase 2 Expression through Inhibiting Peroxisome Proliferator-Activated Receptor-γ in Placental Trophoblasts. J Immunol 2019; 203(5): 1198-1207.(IF: 4.718)

[21]Chen YH, Hu XG, Zhou Y, Yu Z, Fu L, Zhang GB, Bo QL, Wang H, Zhang C, Xu DX*. Obeticholic Acid Protects against Lipopolysaccharide-Induced Fetal Death and Intrauterine Growth Restriction through Its Anti-Inflammatory Activity. J Immunol 2016; 197: 4762-4770.(IF: 4.718)

[22]Chen YH, Zhao M, Chen X, Zhang Y, Wang H, Huang YY, Wang Z, Zhang ZH, Zhang C, Xu DX*. Zinc supplementation during pregnancy protects against lipopolysaccharide-induced fetal growth restriction and demise through its anti-inflammatory effect. J Immunol 2012; 189: 454-463. (IF:4.718)

[23]Li R, Wang X, Wang B, Li J, Song Y, Luo B, Chen Y, Zhang C, Wang H, Xu DX*. Gestational 1-nitropyrene exposure causes gender-specific impairments on postnatal growth and neurobehavioral development in mice. Ecotoxicol Environ Saf 2019; 180: 123-129. (IF: 4.527)

[24]Guo C, Yang Y, Shi MX, Wang B, Liu JJ, Xu DX*, Meng XH*. Critical time window of fenvalerate-induced fetal intrauterine growth restriction in mice. Ecotoxicol Environ Saf 2019; 172: 186-193. (IF: 4.527)

[25]Chen YH, Tao FB, Xu DX*. The Association between Pre-pregnancy Body Mass Index and Risk of Preterm Delivery in Chinese Population. Am J Epidemiol 2018; 187: 1123-1124.(IF: 4.473)

[26]Wang H, Hu YF, Hao JH, Chen YH, Wang Y, Zhu P, Zhang C, Xu YY, Tao FB*, Xu DX*. Maternal serum zinc concentration during pregnancy is inversely associated with risk of preterm birth in a Chinese population. J Nutr 2016; 146(3): 509-515.(IF: 4.416)

[27]Chen YH, Fu L, Hao JH, Wang H, Zhang C, Tao FB, Xu DX*. Influent factors of gestational vitamin D deficiency and its relation to an increased risk of preterm delivery in Chinese population. Sci Rep 2018; 8(1): 3608.(IF: 4.011)

[28]Zhang ZH, Liu XQ, Zhang C, He W, Wang H, Chen YH, Liu XJ, Chen X, Xu DX*. Tlr4-mutant mice are resistant to acute alcohol-induced sterol-regulatory element binding protein activation and hepatic lipid accumulation. Sci Rep 2016; 6: 33513. (IF: 4.011)

[29]Wang H, Liu L, Hu YF, Hao JH, Chen YH, Su PY, Fu L, Yu Z, Zhang GB, Wang L, Tao FB, Xu DX*. Maternal serum cadmium level during pregnancy and its association with small for gestational age infants: a population-based birth cohort study. Sci Rep 2016; 6: 22631. (IF: 4.011)

[30]Xu S, Chen YH, Tan ZX, Xie DD, Zhang C, Zhang ZH, Wang H, Zhao H, Yu DX, Xu DX*. Vitamin D3 pretreatment regulates renal inflammatory responses during lipopolysaccharide-induced acute kidney injury. Sci Rep 2015; 5: 18687. (IF: 4.011)

[31]Chen YH, Yu Z, Fu L, Wang H, Chen X, Zhang C, Lv ZM, Xu DX*. Vitamin D3 inhibits lipopolysaccharide-induced placental inflammation through reinforcing interaction between vitamin D receptor and nuclear factor kappa B p65 subunit. Sci Rep 2015; 5: 10871. (IF: 4.011)

[32]Wang H, Hu YF, Hao JH, Chen YH, Su PY, Wang Y, Yu Z, Fu L, Xu YY, Zhang C, Tao FB, Xu DX*. Maternal zinc deficiency during pregnancy elevates the risks of fetal growth restriction: a population-based birth cohort study. Sci Rep 2015; 5: 11262. (IF: 4.011)