1. 简介

医学博士,副教授,硕士研究生导师。兼任安徽省预防医学会环境卫生专业委员会委员兼秘书,职业卫生与职业病专业委员会委员,安徽省环境诱变剂学会委员。参与多项科研课题,现主持安徽省自然科学基金一项、国家自然科学基金一项。担任Environmental Pollution, Environmental Research等杂志审稿人,在Free Radical Biology and MedicineEnvironmental Pollution等杂志发表论文五十余篇。

主要研究方向:空气污染与生殖健康


2.教育经历

2012/09-2016/06,浙江大学医学院,博士

2001/09-2004/06,安徽医科大学公共卫生学院,硕士

1996/09-2001/06,安徽医科大学公共卫生学院,学士


3.主持项目

1)国家自然科学基金 面上项目,蜕膜基质细胞外泌体circFBXW7_0141-硝基芘抑制胎盘螺旋动脉重铸而诱发胎儿生长受限中的作用,2024/01-2027/1249万,在研,主持

2)安徽省自然科学基金 面上项目,子宫蜕膜基质细胞外泌体circ-CTNNB1影响孕期1-硝基芘暴露致胎儿生长受限中的分子机制2021/01-2023/12, 12万,在研,主持

3)安徽省高校优秀青年人才支持计划项目,组蛋白H3R17me2修饰在烹调油烟PM2.5引起肺癌进展及转移中作用及分子机制,2017/01-2018/12, 3万,已结题,主持

4)安徽省自然科学基金 面上项目Wnt/β -catinen 信号通路在空气污染颗粒物引起 p16 启动子甲基化改变中作用的研究,2017/07-2019/06, 8万,已结题主持

5)安徽医科大学博士科研资助项目,H3R17me2调控的细胞自噬在烹调油烟PM2.5引起肺癌进展及转移中的作用,2017/07-2019/06, 7万,已结题主持

6)安徽省省级质量工程大规模在线开放课程,职业卫生与职业医学,2019/12-2019/1210万,已结题主持

7)安徽医科大学教学研究项目,以课题设计为依托提升预防医学生创新能力,2017/01-2019/121万,已结题主持


4.代表性论文

1.Ju L, Li C, Hua L, Xu H, Hu Y, Zhou X, Sun S, Zhang Q, Cheng H, Yang M, Cao J, Ding R. Uterine decidual stromal cell-derived exosomes mediate the indirect effects of 1-nitropyrene on trophoblast biological behaviors. Ecotoxicol Environ Saf. 2022 Dec 15;248:114288.


2.Ding Rui#, Li Jing#, Zhang Qi#, Zhang Chao, Li Na, Sun Shu, Li Changlian, Shen Chaowei, Zhao Qihong, Cheng Hongbo*, Hao Jiahu*, Cao Jiyu*.Vitamin D3 protects intrauterine growth restriction induced by cooking oil fume derived fine particulate matters. Ecotoxicol Environ Saf. Volume 229, 1 January 2022, 113103


3.Yang M, Ju L, Li C, Cheng H, Li N, Zhang Q, Sun S, Ding L, Sui X, Zhang C, Yang M, Cao J, Ding R. MiR-582-3p participates in the regulation of biological behaviors of A549 cells by ambient PM2.5 exposure. Environ Sci Pollut Res Int. 2021 Sep 30. doi: 10.1007/s11356-021-16801-2.


4.Li Changlian, Ju Liangliang, Yang Mei, Zhang Qi, Sun Sshu, Cao Jiyu*, Ding Rui*. Prenatal air pollution exposure increases the risk of macrosomia: evidence from a prospective cohort study in the coastal area of China. Environ Sci Pollut Res Int. 2021 Aug 21. doi: 10.1007/s11356-021-16054-z.


5.Ju L, Li C, Yang M, Sun S, Zhang Q, Cao J, Ding R. Maternal air pollution exposure increases the risk of preterm birth: Evidence from the meta-analysis of cohort studies.  Environ Res. 2021 Nov;202:111654. doi: 10.1016/j.envres.2021.111654.


6.Li C, Yang M, Zhu Z, Sun S, Zhang Q, Cao J, Ding R. Maternal exposure to air pollution and the risk of low birth weight: A meta-analysis of cohort studies. Environ Res. 2020 Nov;190:109970. doi: 10.1016/j.envres.2020.109970.


7.Yang M, Cheng H, Shen C, Liu J, Zhang H, Cao J, Ding R. Effects of long-term exposure to air pollution on the incidence of type 2 diabetes mellitus: a meta-analysis of cohort studies. Environ Sci Pollut Res Int. 2020 Jan;27(1):798-811. doi: 10.1007/s11356-019-06824-1.


8.Hu H, Zhou Y, Zhang M, Ding R. Prognostic value of RASSF1A methylation status in non-small cell lung cancer (NSCLC) patients: A meta-analysis of prospective studies. Biomarkers. 2019 May;24(3):207-216. doi: 10.1080/1354750X.2019.1583771.


9.Zang H, Cheng H, Song W, Yang M, Han P, Chen C, Ding R. Ambient air pollution and the risk of stillbirth: a population-based prospective birth cohort study in the coastal area of China. Environ Sci Pollut Res Int. 2019 Mar;26(7):6717-6724. doi: 10.1007/s11356-019-04157-7


10.Sun S, Wang X, Ding L, Zhang Q, Li N, Sui X, Li C, Ju L, Zhao Q, Chen H, Ding R, Cao J. Association between preconceptional air pollution exposure and medical purposes for selective termination of pregnancy. Environ Res. 2021 Nov;202:111743. doi: 10.1016/j.envres.2021.111743.


11.Zhang Q, Sun S, Sui X, Ding L, Yang M, Li C, Zhang C, Zhang X, Hao J, Xu Y, Lin S, Ding R, Cao J. Associations between weekly air pollution exposure and congenital heart disease. Sci Total Environ. 2021 Feb 25;757:143821. doi: 10.1016/j.scitotenv.2020.143821.


12.Ding Liu, Sui Xinmiao, Yang Mei, Zhang Qi, Sun Shu, Zhu Furong, Cheng Han, Zhang Chao, Chen Hongbo*, Ding Rui*, Cao Jiyu*. Toxicity of cooking oil fume derived particulate matter: Vitamin D3 protects tubule formation activation in human umbilical vein endothelial cells. Ecotoxicol Environ Saf. 2020 Jan 30;188:109905. doi: 10.1016/j.ecoenv.2019.109905.