代慧，教授,“东南学者”教授，博士生导师，博士后合作导师。国家级高层次青年人才，安徽省高层次人才（C类）、合肥市高层次人才（C类）。2018年12月博士毕业于中国科学技术大学，2019-2024年在美国加利福尼亚大学河滨分校(UCR)进行博士后研究，2025年在香港城市大学担任Research Fellow工作，2026年1月加入安徽医科大学公共卫生学院任独立PI。研究方向聚焦 RNA 修饰调控疾病的发病机制与干预策略，综合利用线虫模式生物、类器官及干细胞构建多层次研究体系，系统解析疾病演进过程中的分子与细胞机制。依托细胞培养、生化分析、分子生物学实验平台，开展 RNA 修饰相关细胞功能检测、组学解析、基因调控与编辑等系列实验，实现从基础机制挖掘到潜在疾病治疗靶点的系统性探索。相关研究工作以第一作者或共同第一作者发表于Nature, Molecular Cell等期刊。课题组长期招聘对分子生物学、细胞生物学、表观转录组学、蛋白组学、分析化学等方向感兴趣的博士后、博士研究生和科研助理。简历发送至：daihui@ahmu.edu.cn

科研项目：

1.主持国家级高层次青年人才项目1项

2.主持国家自然科学基金青年项目1项

2.主持安徽医科大学人才启动基金项目1项

论文著作：

1. Yuxiang Sun*,Hui Dai*, Xiaoxia Dai, Jiekai Yin, Yuxiang Cui, Xiaochuan Liu, Gwendolyn Gonzalez, Jun Yuan, Feng Tang, Nan Wang, Alexandra E. Perlegos, Nancy M. Bonini, X. William Yang, Weifeng Gu, Yinsheng Wang. m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration.Nature, 2023,580-587. (共同一作)IF=48.5

2. Yuxiang Sun, Zhouxian Li,Hui Dai, Yinsheng Wang. m⁶A modulates RAN translation from CAG repeat expansion RNA.Aggregate, 2025, 0:e70072.IF=13.7

3. Daniel A Chaves*,Hui Dai*, Lichao Li, James J Moresco, Myung Eun Oh, Darryl Conte Jr, John R Yates III, Craig C Mello, Weifeng Gu. The RNA phosphatase PIR-1 regulates endogenous small RNA pathways inC. elegans.Molecular Cell2021, 81, 1–12. (共同一作)IF=16.6

4.Hui Dai, Yun Liu, Jingjing Wang, Yaguang Nie, Yuxiang Sun, Mudi Wang, Dayan Wang, Zhen Yang, Lei Cheng, Juan Wang, Jian Weng, Qiuquan Wang, Fangyue Wang, Lijun Wu, Guoping Zhao, An Xu. Graphene oxide antagonizes the toxic response to arsenic via activation of protective autophagy and suppression of the arsenic-binding protein LEC-1 inCaenorhabditis elegans.Environmental Science: Nano, 2018, 1711-1728.IF=5.1

5.Hui Dai, Weifeng Gu. Strategies and best practice in cloning small RNAs. Gene technology 2020,9 (2)

6.Hui Dai, Weifeng Gu. Small RNA Plays Important Roles in Virus–Host Interactions.Viruses 2020,12 (11), 1271. IF=4.7

7. Lichao Li*,Hui Dai*, An-phong Nguyen, Rong Hai and Weifeng Gu. Influenza A virus utilizes noncanonical cap-snatching to diversify its mRNA/ncRNA.RNA 2020, 26 (9), 1170-1183.(共同一作) IF=3.9

8. Yuxiang Sun*,Hui Dai*, Shaopeng Chen, Ming Xu, Xuanyu Wang, Yajun Zhang, Shengmin Xu, An Xu, Jian Weng, Sijin Liu, Lijun Wu. Graphene oxide regulates cox2 in human embryonic kidney 293T cells via epigenetic mechanisms: dynamic chromosomal interactions.Nanotoxicology 2018, 12 (2), 117-137.(共同一作)IF=5.9

9. Jingjing Wang*,Hui Dai*, Yaguang Nie, Mudi Wang, and An Xu. TiO2 nanoparticles enhanced bioaccumulation and toxicity of heavy metals in Caenorhabditis elegans via modification of local concentrations during the sedimentation process.Ecotoxicology and Environmental Safety.(共同一作) IF=6.2

10. Lichao Li, Hui Dai, An-phong Nguyen and Weifeng Gu. A convenient strategy to clone small RNA and mRNA for high-throughput sequencing.RNA 2020, 26 (2), 218-227.IF=3.9