博士、副教授、硕士生导师，安徽省首批高校“双带头人”教师党支部书记工作室负责人、安徽省高校中青年教师培养行动项目学科（专业）带头人培育对象，公共卫生学院党政办公室副主任，公共卫生学院卫生毒理学系党支部书记、副主任。学术兼职：安徽省环境诱变剂学会理事兼秘书、安徽省预防医学会卫生毒理专业委员会委员兼秘书。主要研究方向：发育源性疾病的环境病因与机制研究。主持国家自然科学基金面上项目、青年科学基金、安徽省自然科学基金面上项目、安徽省教育厅高校自然科学研究重点项目、安徽省高等学校省级优秀青年人才基金项目和安徽医科大学校级科学研究基金课题各1项，参与省部级以上课题多项；以第一作者（含共同第一作者）发表SCI论文15篇。曾获安徽省优秀硕士学位论文、安徽省科学技术奖二等奖、中华预防医学科技奖三等奖、华夏医学科技奖三等奖各1项、中华医学科技奖三等奖3项、校优秀教师、校优秀共产党员、校优秀班主任和校优秀校友工作者。

代表性论文

[1]Fan Zhao #, Lun Zhang #, Mingchao Qu, Lu Ye, Jiayi Zhang, Yun Yu, Qianqian Huang, Cheng Zhang*, Jianqing Wang*. Obeticholic acid alleviates intrauterine growth restriction induced by di-ethyl-hexyl phthalate in pregnant female mice by improving bile acid disorder. Environ Sci Pollut Res Int. 2023; 30(51): 110956-110969. 

[2]Bingdong Song#, Cheng Zhang#, Weirong Hu,  Chunyu Guo, Zhengmei Xia , Wanxia Hu, Mingqiang Qin, Weiying Jiang, Jinwei Lv, Dexiang Xu, Shichen Zhang*, Jun Fang*, Nano-designed carbon monoxide donor SMA/CORM2 exhibits protective effect against acetaminophen induced liver injury through macrophage reprograming and promoting liver regeneration, J Control Release, 2021; 331: 350-363.

[3]Cheng Zhang, Yu Gan, Jin-Wei Lv, Ming-Qiang Qin, Wei-Rong Hu, Zhi-Bing Liu, Li Ma, Bing-Dong Song, Jian Li, Wei-Ying Jiang, Jian-Qing Wang, Hua Wang, De-Xiang Xu*, The protective effect of obeticholic acid on lipopolysaccharide-induced disorder of maternal bile acid metabolism in pregnant mice, Int Immunopharmacol, 2020; 83: 106442.

[4]Qian-Qian Chen#, Cheng Zhang#, Ming-Qiang Qin, Jian Li, Hua Wang, De-Xiang Xu*, Jian-Qing Wang*, Inositol-requiring enzyme 1 alpha endoribonuclease specific inhibitor stf-083010 alleviates carbon tetrachloride induced liver injury and liver fibrosis in mice, Front Pharmacol, 2018; 9: 1344.

[5]Da-Gang Zhang#, Cheng Zhang#, Jun-Xian Wang, Bi-Wei Wang, Hua Wang, Zhi-Hui Zhang, Yuan-Hua Chen, Yan Lu, Li Tao, Jian-Qing Wang, Xi Chen*, De-Xiang Xu*, Obeticholic acid protects against carbon tetrachloride-induced acute liver injury and inflammation, Toxicol Appl Pharmacol, 2017; 314: 39-47.

[6]Jun-Xian Wang#, Cheng Zhang#, Lin Fu, Da-Gang Zhang, Bi-Wei Wang, Zhi-Hui Zhang, Yuan-Hua Chen, Yan Lu, Xi Chen*, De-Xiang Xu*, Protective effect of rosiglitazone against acetaminophen-induced acute liver injury is associated with down-regulation of hepatic NADPH oxidases, Toxicol Lett, 2017; 265: 38-46.

[7]Jia-Hui Huang#, Cheng Zhang#, Da-Gang Zhang, Lu Li, Xi Chen*, De-Xiang Xu*, Rifampicin-Induced Hepatic Lipid Accumulation: Association with Up-Regulation of Peroxisome Proliferator-Activated Receptor γ in Mouse Liver, PLoS One; 2016, 11(11): e0165787.

[8]Ye-Fa Zhang#, Wei He#, Cheng Zhang#, Xiao-Jing Liu, Yan Lu, Hua Wang, Zhi-Hui Zhang, Xi Chen*, De-Xiang Xu*, Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice, Toxicol Lett, 2014; 225(3): 445-453.

[9]Jian-Qing Wang#, Xi Chen#, Cheng Zhang#, Li Tao, Zhi-Hui Zhang, Xiao-Qian Liu, Yuan-Bao Xu, Hua Wang, Jun Li*, De-Xiang Xu*, Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice, Toxicol Appl Pharmacol, 2013; 266(2):307-316.

[10]Cheng Zhang#, Xi Chen#, Ren-Min Zhu#, Ying Zhang, Tao Yu, Hua Wang, Hui Zhao, Mei Zhao, Yan-Li Ji, Yuan-Hua Chen, Xiu-Hong Meng, Wei Wei*, De-Xiang Xu*, Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice, Toxicol Lett; 2012, 212(3): 229-240.

[11]Xi Chen#, Cheng Zhang#, Mei Zhao, Chang-E Shi#, Ren-Min Zhu, Hua Wang, Hui Zhao, Wei Wei, Jia-Bin Li, De-Xiang Xu*, Melatonin alleviates lipopolysaccharide-induced hepatic SREBP-1c activation and lipid accumulation in mice, J Pineal Res, 2011; 51(4): 416-425.

[12]Xi Chen#, Cheng Zhang#, Hua Wang, Juan Xu, Zi-Hao Duan, Ying Zhang, Tao Yu, Wei Wei, De-Xiang Xu*, Jian-Ming Xu*, Altered integrity and decreased expression of hepatocyte tight junctions in rifampicin-induced cholestasis in mice, Toxicol Appl Pharmacol, 2009; 240 (1): 26-36.

[13]Xiang-Yun Li#, Cheng Zhang#, Su-Fang Wang, Yan-Li Ji, Hua Wang, Lei Zhao, De-Xiang Xu*, Maternally-administered lipopolysaccharide (LPS) upregulates the expression of heme oxygenase-1 in fetal liver: the role of reactive oxygen species, Toxicol Lett, 2008; 176 (3): 169-177.

[14]Xiang-Yun Li#, Cheng Zhang#, HuaWang, Yan-Li Ji, Su-FangWang, Lei Zhao, Xi Chen, De-Xiang Xu*, Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced downregulation of CYP3A in fetal liver: its repression by a low dose LPS pretreatment, Toxicol Lett, 2008; 179 (2): 71-77.

[15]Cheng Zhang, Xiang-Yun Li, Lei Zhao, Hua Wang, De-Xiang Xu*, Lipopolysaccharide (LPS) up-regulates the expression of haem oxygenase-1 in mouse placenta, Placenta, 2007; 28 (8-9): 951-957.