沈彤，医学博士、教授、博士生导师、博士后合作导师, 澳大利亚昆士兰科技大学（QUT）访问学者，安徽省学术和技术带头人后备人选，安徽医科大学公共卫生学院职业卫生与环境卫生学系主任。兼任中国环境诱变剂学会常务理事及环境与生育健康专委会常务委员、中国职业安全健康协会工业防毒专委会副主任委员、全国公共卫生与预防医学名词编委会环境卫生学名词编写分会委员、安徽省环境诱变剂学会副理事长兼秘书长、安徽省预防医学会常务理事兼职业卫生与职业病专业委员会主任委员，安徽省环境应急专家，安徽省科学技术协会第十届委员会委员。

主持国家自然基金面上项目3项，教育部自然科学研究重点项目和安徽省自然科学基金等省部级项目8项，安徽省高校学科（专业）拔尖人才学术项目1项；发表论文160余篇（SCI收录50多篇），获安徽省科学技术奖3项，授权发明国家专利2项，新型实用专利2项。人民卫生出版社国家级规划教材五年制临床医学专业《卫生学》（第8和9版）、护理专业《预防医学》（第5版）、科学出版社全国高等医药院校规划教材《职业卫生与职业医学》（案例版，第二版）编委，安徽省省级一流课程《职业卫生与职业医学》负责人，安徽省省级一流教材《预防保健学》（第4版）主编；获安徽省教学成果奖2项。任《中华疾病控制杂志》、《环境卫生学杂志》、《职业卫生与应急救援》等杂志编委，Chemosphere、FCT、EES和Environ Res等国际期刊审稿专家。

主要研究方向：职业与环境健康危害的免疫代谢调控

1. 主持的科研项目

[1] 国家自然科学基金面上项目：母体肠道菌群SCFAs-胚胎GPR轴调控孕期双酚A暴露诱导的子代成年期肥胖易感性增加的研究（批准号：82073594），起止年月：2021/01-2024/12;

[2] 国家自然科学基金面上项目：双酚A增加脂肪组织巨噬细胞神经酰胺从头合成介导肥胖衍生的胰岛素抵抗及其机制（批准号：81773467）, 起止年月：2018/01-2021/12；

[3] 国家自然科学基金面上项目：IL-17介导巨噬细胞极化对BPA诱导肥胖中脂肪组织炎症的调控及机制研究（批准号：81473015），起止年月：2015/01-2018/12。

[4] 安徽高校协同创新项目：煤尘诱导肺上皮细胞亚群变化在肺炎症/纤维化中作用及靶向治疗研究（编号：GXXT-2022-065），子课题：生产性粉尘致肺部疾患中免疫代谢调控研究，负责人，起止年月：2023/01-2025/12。

2. 代表性论文（*通讯作者）

[1] Xu Hong^#, Yi Zhou^#, Zhiyuan Zhu, Yuting Li, Zuo Li, Yuheng Zhang, Xinxin Hu, Fuhai Zhu, Yong Wang, Mingliang Fang, Yichao Huang*, Tong Shen*. Environmental endocrine disruptor Bisphenol A induces metabolic derailment and obesity via upregulating IL-17A in adipocytes, Environment International,2023,172, 107759. doi.org/10.1016/j.envint. 2023.107759. (IF:13.352, 中科院1区)

[2] Xiang Zhang^#, Xinxin Hu^#, Yuqing Zhang, Bin Liu, Haihong Pan, Zikai Liu, Zhuomeng Yao, Qixing Zhu, Changhao Wu, Tong Shen*. Impaired autophagy-accelerated senescence of alveolar type II epithelial cells drives pulmonary fibrosis induced by single-walled carbon nanotubes. Journal of Nanobiotechnology, 2023.2. (IF:9.429, 中科院1区)

[3] ZikaiLiu, Yiqun Chen, and Tong Shen. Evidence Based on an Integrative Analysis of Multi-Omics Data on METTL7A as a Molecular Marker in Pan-Cancer. Biomolecules. 2023; 13(2):195. doi.org/10.3390/biom13020195. IF:6.08

[4] Gengfu Wang^#, Geng Xu^#, Chao Zhang^#, Azhu Han, Guobao Zhang, Liru Chen, Guodie Xie, Fangbiao Tao, Tong Shen*, Puyu Su*.Gestational bisphenol A exposure advances puberty onset in female offspring: Critical time window identification. Ecotoxicology and Environmental safety, 2023, 249, 114387.(IF:7.129, 中科院1区)

[5] Xu Hong^#, Gengfu Wang^#, Xingcun Liu, Ming Wu, Xindong Zhang, Xiaohui Hua, Pengpeng Jiang, Sheng Wang, Song Tang, Xiaoming Shi,Yichao Huang*,Tong Shen*. Lipidomic biomarkers: Potential mediators of associations between urinary bisphenol A exposure and colorectal cancer. Journal of Hazardous Materials. 2022. 427(5): 127863. (IF:14.224, 中科院1区)

[6] Xiang Zhang^#, Jiaojiao Zhu^#, Shuxin Yang^#, Zhuomeng Yao, Sujuan Zhao, Yan Wang, Chengfan Zhou, Qixing Zhu, Tong Shen*. IL-4-activated C/EBPβ is involved in alveolar macrophage polarization towards the M2 phenotype during pulmonary fibrosis induced by single-walled carbon nanotubes. Environ. Sci.: Nano, 2022,9, 4233-4248 ( IF:9.473, 中科院1区)

[7] Xiong J^#, Lv Y^#, Wei Y^#, Liu Z, Li X, Zhou J, Liu Y, Zhao F, Chen C, Gu H, Wang J, Zheng X, Xue K, Qiu Y, Shen,T*, Shi X*. Association of blood mercury exposure with depressive symptoms in the Chinese oldest old. Ecotoxicology and environmental safety, 2022, 243, 113976. (IF:7.129, 中科院1区)

[8] Zhang XL^#, Li B^#, Zhang X, Zhu J, Xie Y, Shen T*, Tang W*, Zhang J*. 18β-Glycyrrhetinic acid monoglucuronide (GAMG) alleviates single-walled carbon nanotubes (SWCNT)-induced lung inflammation and fibrosis in mice through PI3K/AKT/NF-κB signaling pathway. Ecotoxicology and environmental safety. 2022;242:113858. ( IF:7.129, 中科院1区)

[9] Hu X, Zhou R, Hu M, Wen J, Shen T*. Differentiation and prediction of pneumoconiosis stage by computed tomography texture analysis based on U-Net neural network.” Computer methods and programs in biomedicine vol. 225 (2022): 107098. ( IF:7.027)

[10] Hu X, Tao J, Zheng H, Ding Z, Cheng J, Shen T*. Impact of cold spells on COPD mortality in Jiangsu Province, China. Environ Sci Pollut Res Int. 2022; 10. 1007/s11356-022-22387-0. ( IF:5.190)

[11] Xiang Zhang, Min Luo, Jiaxiang Zhang, Zhuomeng Yao, Jiaojiao Zhu, Shuxin Yang, Qixing Zhu, Tong Shen*. Carbon nanotubes promote alveolar macrophages toward M2 polarization mediated epithelial-mesenchymal transition and fibroblast-to- myofibroblast transdifferentiation. Nanotoxicology, 2021.15(5):588-604. (IF:5.913, 中科院1区)

[12]Sujuan Zhao, Chunyang Yuan, Xun Tuo, Chengfan Zhou, Qihong Zhao, Tong Shen*.  CLR induces dysregulation of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in Sertoli cell. Chemosphere. 2021.263: 127868.(IF: 8.943)

[13] Gengfu Wang, Yingpei Li,Yun Li,Jiaxiang Zhang,Chengfan Zhou,Changhao Wu,Qixing Zhu*,Tong Shen*.Maternal vitamin D supplementation inhibits bisphenol A-induced proliferation of Th17 cells in adult offspring. Food and Chemical Toxicology. 2020. 144: 111604. (IF:6.023,中科院1区)

[14] Jiaxiang Zhang, Na Li, QiongYing Xu, Yi Yang, HaiBo Xie, Tong Shen*, Qixing Zhu*. Kupffer cell depletion attenuates IL-6/STAT3 mediates hepatocyte apoptosis in immunological liver injury of trichloroethylene sensitized mice. International Immunopharmacolog. 2020. 88: 106897.

[15] Zhang JX, Xu QY, Yang Y, Li N, Zhang Y, Deng LH, Zhu QX*, Shen T*. Kupffer cell inactivation ameliorates immune liver injury via TNF-α/TNFR1 signal pathway in trichloroethylene sensitized mice. Immunopharmacology and Immunotoxicology. 2020. 42(6): 545-555.

[16]Zhang JX, Li N, Yang L, Xie HB, Yang Y, Wang H, Wu CH, Shen T*, Zhu QX*. Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: a role in Kupffer cell activation. Toxicology. 2019. 415, 37- 48.

[17] Xiaotong Lu, Meiling Li, Changhao Wu, Chengfan Zhou, Jiaxiang Zhang, Qixing Zhu*, Tong Shen*. Bisphenol A promotes macrophage proinflammatory subtype polarization via upregulation of IRF5 expression in vitro. Toxicology in Vitro. 2019. 60, 97-106.

[18] Bai YW, Ye MJ, Yang DL, Yu MP, Zhou CF*, Shen T*. Hydrogen sulfide attenuates paraquat‐induced epithelial‐mesenchymal transition of human alveolar epithelial cells through regulating transforming growth factor‐β1/Smad2/3 signaling pathway. Journal Applied Toxicology. 2019. 39(3):432-440.

[19] Zhang J, Li N, Yang L, Zang D, Yang P, Wang H, Shen T*, Zhu QX*. Role of selective blocking of bradykinin B1 receptor in attenuating immune liver injury in trichloroethylene-sensitized mice. Cytokine. 2018. 108:71-81.

[20]Zhang C, Yu Y, Yu JF, Li BD, Zhou CF, Yang XD, Wang X, Wu CH, Shen T*, Zhu QX*. Viral mimic polyinosine-polycytidylic acid potentiates liver injury in trichloroethylene-sensitized mice-Viral-chemical interaction as a novel mechanism. Ecotoxicology and Environmental safety, 2018.155:101-108.

[21]Luo SM，Li Y，Li YP，Zhu QX，Jiang JH，Wu CH，Shen T*.Gestational and lactational exposure to low-dose bisphenol A increases Th17 cells in mice offspring. Environmental Toxicology and Pharmacology. 2016. 47:149~158.

3.获奖情况

[1] 安徽省科技进步奖三等奖：职业性三氯乙烯药疹样皮炎发病机制研究，安徽省人民政府，2016年，排名第一

[2] 安徽省科技进步奖三等奖：减重代谢手术治疗肥胖症及2型糖尿病的临床和基础研究, 安徽省人民政府，2020年，排名第二

4.专利

[1]发明专利：发明人：胡欣欣，沈彤，文静；名称：一种尘肺病康复理的加氧雾化吸入器；申请专利号:202210407715.3；中国；

[2]发明专利：发明人：胡欣欣，沈彤；名称：一种尘肺病治疗用的雾化装置；授权专利号:CN 113041462 B；授权国家:中国；

[3]实用新型专利：发明人：胡欣欣，沈彤，文静；实用新型名称：一种尘肺状态呼吸演示教学设备；专利号:ZL202120957340.9；

[4]实用新型专利：发明人：胡欣欣，沈彤，文静；名称:一种用于尘肺患者的呼吸训练康复装置；授权专利号:CN 216258985 U；授权国家:中国；