杨万水

   

       杨万水(1982~),安徽潜山人,医学博士,教授,博士生导师。2013年毕业于复旦大学公共卫生学院获流行病与卫生统计学博士学位。现任安徽医科大学公共卫生学院营养与食品卫生学系主任。分别担任中国抗癌协会与安徽省抗癌协会肿瘤流行病专委会青年委员与副主委,受邀担任10多个中英文期刊审稿人。近年来主持国家自然科学基金2项,主持其它省部级以上课题4项。

       主要聚焦饮食与肝癌及结直肠癌的病因与预后,主要发现可修饰炎症与胰岛素抵抗的相关膳食因素可影响肝癌与大肠癌的发生与发展,并进一步揭示癌症发生与预后的异质性。相关成果以第一或通讯作者发表在JAMA OncologyGutHepatologyAnnals of Oncology等权威杂志,其中肝癌与肠癌的部分结果写入国际抗癌指南中。副主编本科与专科教材各1部,分别由人民卫生出版社与科学技术出版社出版,作为编委参编研究生教材《流行病学原理》(第2版)1部,即将由复旦大学出版社出版。详见ResearchGate个人主页(https://www.researchgate.net/profile/Wanshui_Yang)。欢迎有志致力于营养流行病与肿瘤流行病学研究的同行或同学加入我们课题组。Email: wanshuiyang@hotmail.comwanshuiyang@gmail.com

 

1.    近五年主持的主要课题

  炎症与胰岛素相关膳食模式及其代谢组学标志物与肝癌发生关系的前瞻性研究,国家自然科学基金(项目号:82073651),57

  睡眠因素与MTNR1AMTNR1BSNAT基因多态性及其交互作用在乳腺癌发生中作用的研究,国家自然科学基金(项目号:81460514),60

  膳食钙、维生素D与肿瘤微环境中钙敏感受体、维生素D受体以及相关原癌基因突变在结直肠癌预后中的作用,安徽省自然科学基金(项目号:2008085MH262),12

  肿瘤与营养流行病学,安徽医科大学人才启动经费(项目号:XJ201935),100

2.    代表作列表

2.1 肝癌领域

  Yang W, Ma Y, Liu Y, Smith-Warner SA, Simon TG, Chong DQ, Qi Q, Meyerhardt JA, Giovannucci EL, Chan AT, Zhang X*. Association of Intake of Whole Grains and Dietary Fiber With Risk of Hepatocellular Carcinoma in US Adults. JAMA Oncol. 2019; 5:879-886.

  Yang W, Shu XO, Gao J, Li HL, Cai H, Yang G, Ji BT, Rothman N, Gao YT, Zheng W, Xiang YB*. Prospective evaluation of type 2 diabetes mellitus on the risk of primary liver cancer in Chinese men and women. Ann Oncol.2013; 24:1679-1685.

  Yang W#, Sui J#, Ma Y, Simon TG, Petrick JL, Lai M, McGlynn KA, Campbell PT, Giovannucci EL, Chan AT, Zhang X*. High Dietary Intake of Vegetable or Polyunsaturated Fats is Associated With Reduced Risk of Hepatocellular Carcinoma. Clin Gastroenterol Hepatol. 2020.

  Ma Y#, Yang W#, Simon TG, Smith-Warner SA, Fung TT, Sui J, Chong D, VoPham T, Meyerhardt JA, Wen D, Giovannucci EL, Chan AT, Zhang X*. Dietary Patterns and Risk of Hepatocellular Carcinoma Among U.S. Men and Women. Hepatology. 2019; 70:577-586.

  Liu Y#, Yang W#, VoPham T, Ma Y, Simon TG, Gao X, Chan AT, Meyerhardt JA, Giovannucci EL, Zhang X*. Plant-based and animal-based low-carbohydrate diets and risk of hepatocellular carcinoma among US men and women. Hepatology. 2020.

2.2结直肠癌领域

  Yang W#, Liu L#, Masugi Y#, Qian ZR, Nishihara R, Keum N, Wu K, Smith-Warner S, Ma Y, Nowak JA, Momen-Heravi F, Zhang L, Bowden M, Morikawa T, Silva AD, Wang M, Chan AT, Fuchs CS, Meyerhardt JA, Ng K, Giovannucci E, Ogino S*, Zhang X*. Calcium intake and risk of colorectal cancer according to expression status of calcium-sensing receptor (CASR). Gut. 2018; 67:1475-1483.

  Yang W#, Ma Y#, Smith-Warner S, Song M, Wu K, Wang M, Chan AT, Ogino S, Fuchs CS, Poylin V, Ng K, Meyerhardt JA, Giovannucci EL, Zhang X*. Calcium Intake and Survival after Colorectal Cancer Diagnosis. Clin Cancer Res. 2019; 25:1980-1988.

  Yang W#, Sui J#, Ma Y, Simon TG, Chong D, Meyerhardt JA, Willett WC, Giovannucci EL, Chan AT, Zhang X*. A prospective study of dairy product intake and the risk of hepatocellular carcinoma in U.S. men and women. Int J Cancer. 2020;147:920-930.

  Yang W#, Liu L#, Keum N, Qian ZR, Nowak JA, Hamada T, Song M, Cao Y, Nosho K, Smith-Warner SA, Zhang S, Masugi Y, Ng K, Kosumi K, Ma Y, Garrett WS, Wang M, Nan H, Giannakis M, Meyerhardt JA, Chan AT, Fuchs CS, Nishihara R, Wu K, Giovannucci EL, Ogino S, Zhang X*. Calcium Intake and Risk of Colorectal Cancer According to Tumor-infiltrating T Cells. Cancer Prev Res (Phila). 2019; 12:283-294.

2.3 流行病学方法学领域

  Yang W*, Fu WX, Wang X, Deng Q, Wang L, Wang LY, Zhao H, Fan WY, Huang SX. Comprehensive assessments of long-term sleep habits in epidemiological study: Validity and reliability of sleep factors questionnaire (SFQ) among Chinese women. J Psychosom Res. 2017; 95:12-18.

  李海容,王莹莹,曾旭芬,李修德,王素芳,张庄,杨万水*. 替代分析在营养流行病学中的应用. 中国卫生统计. 2020.

  曾旭芬,李海容,王莹莹,李修德,张庄,王素芳,杨万水*. 基于降秩回归构建促胰岛素抵抗膳食模式及其与高血压的关系. 营养学报. 2020.